Electrospray ionization-ion mobility spectrometry as a detection system for three-phase hollow fiber microextraction technique and simultaneous determination of trimipramine and desipramine in urine and plasma samples.
Authors: Jafari MT, Saraji M, Sherafatmand H A novel method based on three-phase hollow fiber microextraction technique (HF-LPME) coupled with electrospray ionization-ion mobility spectrometry (ESI-IMS) was developed for the simultaneous determination of two antidepressant drugs (trimipramine and desipramine) in urine and plasma samples. The effects of various parameters such as type of organic solvent, composition of donor and acceptor phase, stirring rate, salt addition, extraction time, and temperature were investigated. Under the optimized conditions, the relative standard deviation was in the range of 5-6%, and the method quantitation limit (MQL) of utilizing HF-LPME/ESI-IMS was 5 μg/L for both drugs. The relative recoveries obtained by the proposed method from urine and plasma ...

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No Advantage of Increased SSRI Dose Seen for Treatment-Resistant Panic DisorderStudy: Antiepileptics Do Not Increase Risk of Suicide Attempts in Bipolar PatientsRaltegravir and LamotrigineCardiometabolic Risk with Antipsychotic Use in Children and TeensTarenflurbil for Cognitive Decline in Patients with Mild ADCommentary by Naomi M. Simon, M.D., M.Sc.Broader View Required in Late-Life Dementia ResearchSSRIs for Patients Recovering from Acute Coronary SyndromesOlanzapine-Induced Tardive Oculogyric CrisisApprovals: Geodon for Maintenance Treatment of Bipolar I in AdultsApprovals: First Generic Version of Aricept: Donepezil HydrochlorideWarnings: Extreme Caution Advised for Desipramine (Norpramin)Correction (Source: The Brown University Psychopharmacology Update)