Inactivation of GPR30 reduces growth of triple-negative breast cancer cells: possible application in targeted therapy
Abstractnbsp;nbsp;Triple-negative breast cancers lack estrogen receptor α (ERα), progesterone receptor, and do not overexpress human epidermal growth factor receptor 2 (Her-2). They are neither susceptible to endocrine therapy nor to a therapy using the anti-Her-2 antibody, trastuzumab. Therefore, an efficient targeted therapy is warranted. Triple-negative breast tumors frequently express membrane bound estrogen receptor G-protein coupled receptor (GPR30). As proof of principle, we analyzed the consequences of a knock-down of GPR30 expression on the growth regulation of triple-negative breast cancer cell lines. Cells of triple-negative breast cancer cell lines were transfected with siRNA against GPR30 or control siRNA, and cell growth was stimulated either with 10−9 M 17β-estr...

Abortion doesn't up risk of mental illness relapse
NEW YORK (Reuters Health) - In women with a history of mental illness such as schizophrenia and bipolar disorder, getting an abortion does not increase their chances of landing in a psychiatric facility again, suggests a new study from Denmark. (Source: Reuters: Health)