17{beta}-Estradiol induces nongenomic effects in renal intercalated cells through G protein-coupled estrogen receptor 1
Steroid hormones such as 17beta;-estradiol (E2) are known to modulate ion transporter expression in the kidney through classic intracellular receptors. Steroid hormones are also known to cause rapid nongenomic responses in a variety of nonrenal tissues. However, little is known about renal short-term effects of steroid hormones. Here, we studied the acute actions of E2 on intracellular Ca2+ signaling in isolated distal convoluted tubules (DCT2), connecting tubules (CNT), and initial cortical collecting ducts (iCCD) by fluo 4 fluorometry. Physiological concentrations of E2 induced transient increases in intracellular Ca2+ concentration ([Ca2+]i) in a subpopulation of cells. The [Ca2+]i increases required extracellular Ca2+ and were inhibited by Gd3+. Strikingly, the classic E2 receptor ant...

Effect of Ethinyl estradiol/ Levonorgestrel combined oral contraceptive on the activity of Cytochrome P4503A in obese women.
Conclusions:  Although we hypothesized that obesity exposure might amplify the impact on CYP3A4/5 activity in COC users, we found that this was not the case. This finding is reassuring regarding potential additional drug‐drug interactions in obese COC users as CYP3A4/5 is a major player in the metabolism of many marketed drugs.© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society (Source: British Journal of Clinical Pharmacology)