Mcm2 phosphorylation and the response to replicative stress
Conclusions: Together these observations point to a role for DDK-mediated phosphorylation of Mcm2 inthe response to replicative stress, including some forms of DNA damage. We suggest thatphosphorylation of Mcm2 modulates Mcm2-7 activity resulting in the stabilization ofreplication forks in response to replicative stress. (Source: BMC Genetics - Latest articles)

London Cancer New Drugs Group Rapid Review: Oxaliplatin and fluorouracil for second line treatment of advanced pancreatic cancer
Source: London Cancer New Drugs Group Area: Evidence #62; Drug Specific Reviews Pancreatic cancer is the fifth leading cause of cancer death in the UK and has a grim prognosis, with 5 year survival of only 3%. Approximately 82% of people diagnosed with pancreatic cancer will die within a year as most have late stage disease at the time of diagnosis.1 Patients with metastatic disease survive 3 to 6 months dependent on the extent of the disease and performance status.2 The incidence of pancreatic cancer in the UK is 9.4/100,000.1 In 2008, 8085 people were newly diagnosed with pancreatic cancer in the UK and 8047 people died from the disease in 2009. There has been no improvement in the UK mortality rate for pancreatic cancer since 1955.1 #160; As the majority of cases are diagnosed at...