Prenatal Programming by Testosterone of Hypothalamic Metabolic Control Neurones in the Ewe
Abstract:Ewes treated prenatally with testosterone (T) develop metabolic deficits, including insulin resistance, in addition to reproductive dysfunctions that collectively mimic polycystic ovarian syndrome (PCOS), a common endocrine disease in women. We hypothesised that metabolic deficits associated with prenatal T excess involve alterations in arcuate nucleus (ARC) neurones that contain either agouti‐related peptide (AgRP) or proopiomelanocortin (POMC). Characterization of these neurones in the ewe showed that immunoreactive AgRP and POMC neurones were present in separate populations in the ARC, that AgRP and POMC neurones co‐expressed either neuropeptide Y or cocaine‐ and amphetamine‐regulated transcript, respectively, and that each population had a high degree of colocalization...

Potential for growth?
Proper nutrition in the womb and in the first two years of a baby’s life is the foundation of a healthy life, writesRONAN McGREEVY (Source: The Irish Times - Health)div id=medwormpbiMedWorm Sponsor Message:/i/b Have a look at a href=http://www.thepsychologydaily.comThe Psychology Daily/a, the new psychology portal powered by MedWorm, with all the latest psychology news and research updated daily./p/div