Half a Century of Hydrochlorothiazide: Facts, Fads, Fiction, and Follies
Abstract: Hydrochlorothiazide (HCTZ) has become by far the most commonly prescribed antihypertensive drug in the US. In 2008, 47.8 million prescriptions were written for HCTZ alone and 87.1 million prescriptions for HCTZ combinations. However, there is no evidence that HCTZ in its usual dose of 12.5-25 mg daily reduces myocardial infarction, stroke, or death. In a meta-analysis of 19 randomized trials with over 1400 patients, the 24-hour decrease in blood pressure with HCTZ was inferior to angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, and calcium channel blockers (P (Source: The American Journal of Medicine)

Genetic Abnormalities Increase Risk for Prostate Cancer DeathGenetic Abnormalities Increase Risk for Prostate Cancer Death
Androgen receptor gene amplification carries up to a 10-fold risk for death in prostate cancer. Medscape Medical News (Source: Medscape Today Headlines)