Toxicity of mixtures of perfluorooctane sulphonic acid with chlorinated chemicals and lipid regulators.
Authors: Boltes K, Rosal R, García-Calvo E Abstract The toxicological interaction of perfluorooctane sulphonic acid (PFOS) with the chlorinated pollutants triclosan and 2,4,6-trichlorophenol and the lipid regulators gemfibrozil and bezafibrate was evaluated using the combination index-isobologram equation. The endpoint for bioassays was the growth rate inhibition of the green alga Pseudokirchneriella subcapitata. The results showed that most of the binary combinations assayed exhibited antagonism at all effect levels. The addition of a third component induced a less antagonistic or even synergistic behaviour. This was particularly marked for the ternary mixture of triclosan and 2,4,6-trichlorophenol with PFOS, for which synergism was very strong at all effect levels, with a combin...

Gemfibrozil/warfarin interaction: Increased INR: case report.
Page: 14 (Source: Reactions Weekly)