Acute GI Bleeding After Percutaneous Coronary InterventionAcute GI Bleeding After Percutaneous Coronary Intervention
Gastrointestinal bleeding can sometimes occur after cardiovascular surgeries such as PCI. How can cardiologists and gastroenterologists work together to come up with a way to both prevent and treat this bleeding? Expert Review of Gastroenterology and Hepatology (Source: Medscape Today Headlines)

Synthetic protection short interfering RNA screen reveals glyburide as a novel radioprotector.
Authors: Jiang J, McDonald PR, Dixon TM, Franicola D, Zhang X, Nie S, Epperly LD, Huang Z, Kagan VE, Lazo JS, Epperly MW, Greenberger JS Abstract To assist in screening existing drugs for use as potential radioprotectors, we used a human unbiased 16,560 short interfering RNA (siRNA) library targeting the druggable genome. We performed a synthetic protection screen that was designed to identify genes that, when silenced, protected human glioblastoma T98G cells from gamma-radiation-induced cell death. We identified 116 candidate protective genes, then identified 10 small molecule inhibitors of 13 of these candidate gene products and tested their radioprotective effects. Glyburide, a clinically used second-generation hypoglycemic drug, effectively decreased radiation-induced cell death in...