Are prescribed doses of medicine for children measurable?
Conclusion The study found that one in eight prescribed doses of liquid medicine for children and neonates cannot physically be measured. The measurability of prescribed doses of medicine must be addressed. Ideally this consideration should take place at the time of prescribing or be reviewed by the pharmacist prior to administering the first dose. Resolving the widespread problem of immeasurable doses is complicated by the fact that concentrations of medicine vary widely. For example 24 mg of paracetamol liquid is sensible and can be measured. However 5 mg of dexamethasone is immeasurable and would better be prescribed as 4.95 mg? Further research to explore the measurability of doses of liquid medicines and the relationship with medicines that have a narrow therapeutic window should be u...

Non surgical therapy for anal fissure.
CONCLUSIONS: Medical therapy for chronic anal fissure, currently consisting of topical glyceryl trinitrate, botulinum toxin injection or the topical calcium channel blockers nifedipine or diltiazem in acute and chronic fissure and fissure in children may be applied with a chance of cure that is marginally better than placebo. For chronic fissure in adults all medical therapies are far less effective than surgery. A few of the newer agents investigated show promise based only upon single studies (clove oil, sildenifil and a healer cream) but lack comparison to more established medications. PMID: 22336789 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)