Pramipexole is active in depression tests and modulates monoaminergic transmission, but not brain levels of BDNF in mice.
In conclusion, the present data substantiate antidepressive effects of pramipexole and indicate a contribution of the dopaminergic and serotonergic metabolism in these effects, but argue against an eminent role of BDNF. PMID: 22206815 [PubMed - as supplied by publisher] (Source: European Journal of Pharmacology)

Changes in hippocampal gene expression by 7‐nitroindazole in rats submitted to forced swimming stress
In this study, genomic and proteomic analyses were used to investigate the effects of the preferential nNOS inhibitor 7‐nitroindazole (7‐NI) on changes in global gene and protein expression in the hippocampus of rats submitted to forced swimming test (FST). Chronic treatment (14 days, i.p.) with imipramine (15 mg/kg daily) or 7‐NI (60 mg/kg daily) significantly reduced immobility in the FST. Saturation curves for Serial analysis of gene expression libraries showed that the hippocampus of animals submitted to FST presented a lower number of expressed genes compared to non‐FST stressed groups. Imipramine, but not 7‐NI, reverted this effect. GeneGo analyses revealed that genes related to oxidative phosphorylation, apoptosis and survival controlled by HTR1A signaling and cytoskeleton...