Slozem (diltiazem) capsules - Revised SPC
Source: eMC (electronic Medicines Compendium) Area: Other Library Updates #62; SPC Changes There have been significant updates to the following section of the SPC: #160; Change to section 4.5 - Interaction with other medicinal products and other forms of interaction #160; Tricyclic antidepressants: diltiazem increases plasma concentration of imipramine. #160; Diltiazem possibly increases plasma concentration of tricyclic antidepressants. #160; Please refer to SPC link below for full information on all changes (Source: NeLM - SPC Changes)

Behavioural phenotyping of knockout mice for the sigma-1 ({sigma}1) chaperone protein revealed gender-related anxiety, depressive-like and memory alterations
The sigma-1 (1) protein regulates calcium homeostasis and acts as an endoplasmic reticulum chaperone. It can be activated by ligands which impact memory, depression, anxiety or addiction processes. We here characterized the behavioural phenotype of knockout (KO) mice for the 1 protein. Two-month old male 1 ndash;/ndash; mice showed signs of anxiety in the open-field, passive avoidance or elevated plus-maze test, but other activity or memory responses were unchanged. Female 1 ndash;/ndash; mice showed deficits in spontaneous alternation or water-maze learning. Twelve-month old 1 +/ndash; female mice showed deficits in alternation and 1 ndash;/ndash; mice in avoidance escape latency. Two- and 14-month old female 1 ndash;/ndash; mice showed decrease...