Prohypertensive effects of non-steroidal anti-inflammatory drugs are mostly due to vasoconstriction.
The objective of this investigation was to determine the level of prohypertensive effects of two NSAIDs (ibuprofen, piroxicam) and paracetamol, co-prescribed with two antihypertensive drugs (lisinopril + hydrochlorothiazide, amlodipine), and to improve the understanding of this interaction. A prospective clinical trial, conducted in a Croatian family practice, included 110 already treated hypertensive patients, aged 56-85 years; 50 control patients and 60 patients who were also taking NSAIDs for osteoarthritis treatment. The antihypertensive regimens remained the same during this study, while NSAIDs and paracetamol were crossed-over in three monthly periods. Blood pressure, body weight, serum creatinine, potassium, sodium, diuresis and 24 h urinary sodium excretion were followed-up. In the...

Heart Failure Drugs Preserve Muscle in Muscular Dystrophywww.parentprojectmd.org
Heart Failure Drugs Preserve Muscle in Muscular Dystrophy Two common drugs used to treat heart failure might also improve heart and muscle function in Duchenne, according to a new study at Ohio State University. Early treatment with lisinopril and spironolactone significantly preserves heart and skeletal muscle tissue in an animal model of the disease. August 2, 2011 | Read more (Source: Parent Project Muscular Dystrophy)