Protective effects of selenium on methimazole nephrotoxicity in adult rats and their offspring.
This study aims to investigate the improving effects of selenium on methimazole-induced kidney impairments in adult rats and their pups. The animals were randomly divided into four groups of six each: group I served as control which received standard diet; group II received only methimazole in drinking water as 250mg/l; group III received both methimazole (250mg/l, orally) and selenium (0.5mg/kg of diet); group IV served as a positive control and received selenium (0.5mg/kg of diet) as sodium selenite (Na(2)SeO(3)). Treatments were started from the 14th day of pregnancy until day 14 after delivery. In the methimazole-treated group, body and absolute kidney weights decreased in pups and their mothers when compared to control. Daily urine volume, plasma creatinine levels were higher, while u...

FELIMAZOLE (Methimazole) Tablet, Sugar Coated [Dechra Veterinary Products]
Updated Date: Mar 29, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))