Cell membrane lytic action of metoclopramide and its relation to tardive dyskinesia
AbstractThe long‐term use of many antipsychotic medications carries a risk of tardive dyskinesia in a small proportion of patients. Although metoclopramide is an antipsychotic at high doses, this drug is more commonly used at low daily doses to accelerate stomach movement of food. Because prolonged use of metoclopramide has also been associated with tardive dyskinesia, this drug is convenient to study in order to examine the possible basis of tardive dyskinesia. Previous work proposed that antipsychotics accumulated in the melanin granules of the human substantia nigra, ultimately building up to high concentrations that could disrupt cell membranes of nigral neurons. While previous work demonstrated the accumulation of metoclopramide in post‐mortem human nigral tissue, it remained to b...

Michael J. Fox, Rick Hansen honoured with stamps
Michael J. Fox, Rick Hansen, Sheila Watt-Cloutier and Louise Arbour are being honoured in a series of quot;difference makerquot; stamps. (Source: CTV Health)