Effect of different immunosuppressive regimens on the evolution of distinct metabolic parameters: evidence from the Symphony study
Conclusions. This sub-analysis demonstrates that there is a difference in metabolic parameters between immunosuppressive groups. CsA therapy was associated with the highest values of uric acid and systolic and diastolic blood pressure. Patients on SRL therapy had the worst lipaemic control. A possible effect of Tac on new-onset diabetes could not be excluded. (Source: Nephrology Dialysis Transplantation)

Immune responses against islet allografts during tapering of immunosuppression – A pilot study in 5 subjects
AbstractTransplantation of isolated islet of Langerhans cells has great potential as a cure for type 1 diabetes but continuous immune suppressive therapy often causes considerable side effects. Tapering of immunosuppression in successfully transplanted patients would lower patients’ health risk.To identify immune biomarkers that may prove informative in monitoring tapering, we studied the effect of tapering on islet auto‐ and alloimmune reactivity in a pilot study in five transplant recipients in vitro. Cytokine responses to the graft were measured using Luminex technology. Avidity of alloreactive cytotoxic T Lymphocytes (CTL) was determined by CD8 blockade. The influence of immunosuppression was mimicked by in vitro replenishment of tacrolimus and MPA, the active metabolite of mycophe...