Stereoselective Inhibitory Effect of Flurbiprofen, Ibuprofen and Naproxen on Human Organic Anion Transporters hOAT1 and hOAT3
In this study, we performed uptake experiments using Xenopus laevis oocytes to assess stereoselectivity in the inhibitory characteristics of flurbiprofen, ibuprofen and naproxen against hOAT1 and hOAT3. Uptake of p‐aminohippurate by hOAT1 was inhibited by each enantiomer of the three NSAIDs, and the inhibitory effect was superior in each (S)‐enantiomer around 10 μM. The apparent 50% inhibitory concentrations were estimated to be 0.615 μM for (S)‐flurbiprofen, 2.84 μM for (S)‐ibuprofen and 1.93 μM for (S)‐naproxen, and these values were significantly lower than those of the respective (R)‐enantiomers [(R)‐flurbiprofen: 2.35 μM, (R)‐ibuprofen: 6.14 μM, (R)‐naproxen: 5.26 μM]. Furthermore, the (S)‐NSAIDs at 3 μM reduced methotrexate accumulation in ...

NSAID-sensitive antihistamine-induced urticaria/angioedema.
We describe the first case of a possible new subset of antihistamine urticaria, and suggest calling this NSAID-sensitive antihistamine-induced urticaria/angioedema. PMID: 21995184 [PubMed - indexed for MEDLINE] (Source: Journal of Investigational Allergology and Clinical Immunology)