Adenoviral-mediated expression of dihydropyridine-insensitive L-type calcium channels in cardiac ventricular myocytes and fibroblasts.
Authors: Walsh KB, Zhang J, Fuseler JW, Hilliard N, Hockerman GH Cardiac voltage-gated Ca(2+) channels regulate the intracellular Ca(2+) concentration and are therefore essential for muscle contraction, second messenger activation, gene expression and electrical signaling. As a first step in accessing the structural versus functional properties of the L-type Ca(2+) channel in the heart, we have expressed a dihydropyridine (DHP)-insensitive Ca(V)1.2 channel in rat ventricular myocytes and fibroblasts. Following isolation and culture, cells were infected with adenovirus expressing either LacZ or a mutant Ca(V)1.2 channel (Ca(V)1.2DHP(i)) containing the double mutation (T1039Y Q1043M). This mutation renders the channel insensitive to neutral DHP compounds such as nisoldipine. The wh...div id=medwormpbiMedWorm Message:/i/b Please support the a href=http://www.doctorsinchains.org/ target=_blankDoctors In Chains/a campaign for the a href=http://www.doctorsinchains.org/medics/a tortured and sentenced for up to 15 years in a href=http://www.doctorsinchains.org/Bahrain/a. a href=https://twitter.com/#!/search/%23FreeDoctors#FreeDoctors/a/p/div

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