Enantio- and Diastereoselective Nitro-Mannich Reactions with in situ Generated N-Boc-imines Catalyzed by a Bifunctional Thiourea-Guanidine Catalyst
SynlettDOI: 10.1055/s-0031-1289885AbstractThe asymmetric nitro-Mannich reactions of nitroalkanes and in situ generated N-Boc-imines were achieved with a new type of thiourea-guanidine bifunctional organocatalyst. The novel transformations exhibited good diastereoselectivities, and the adducts bearing adjacent chiral centers were generally obtained in moderate to high enantioselectivities (up to 94% ee). This reaction provides a concise and alternative route converting readily accessible and stable N-carbamate amido sulfones into optically active 1,2-diamino compounds.[...]© Georg Thieme Verlag Stuttgart ˙ New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Synlett)div id=medwormpbiMedWorm Message:/i/b Find the best a href=http://www.januarysales.org/ target=_blankJanuary Sales/a in the UK./p/div

Who's the boss? A new mom living with her parents wants to know
When a single mother move back home with her baby, the grandparents want to take charge. (Source: USATODAY.com Health)