Impact of intracoronary administration of nitroprusside vs. nitroglycerine before balloon dilatation on slow reflow during percutaneous coronary intervention in patients with acute ST elevation myocardial infarction
Retrospective data have shown that selective intracoronary administration of nitroprusside prior to percutaneous coronary intervention (PCI) is safe, prevents no or slow reflows and improves reperfusion of the infarcted myocardium for acute myocardial infarction (AMI). There is paucity of prospective data regarding the usefulness of this therapy. (Source: Cardiovascular Revascularization Medicine)div id=medwormpbiMedWorm Message:/i/b Please have a look at this new site driven by MedWorm: a href=http://www.thebreastcancerdaily.com/ target=_blankThe Breast Cancer Daily/a/p/div

Regulation of asthmatic airway relaxation by estrogen and heat shock protein 90
AbstractWe tested the hypothesis that asthmatic mouse airways exhibit impaired relaxation to NO donors. Mouse tracheal rings were incubated overnight in serum from asthmatic human subjects or from non‐asthmatic controls. The next day, cumulative concentration‐response curves (CCRC) to sodium nitroprusside (SNP) and nitroglycerine (NTG) were obtained. Both SNP and NTG relaxed the pre‐constricted normal tracheal rings. Tracheal rings exposed to serum from asthmatic patients exhibited a more than a 3‐fold increase in the EC50 of SNP and NTG. Pre‐incubation of tracheal rings with heat shock protein 90 inhibitors decreased the relaxation of both normal and asthmatic tracheal rings to SNP and NTG. Pre‐incubation with estradiol did not affect normal tracheal ring relaxation but exhibi...