α2- and β-adrenoceptors involvement in nortriptyline modulation of auditory sustained attention and impulsivity
Conclusionsnbsp;nbsp;We conclude that sustained attention displays an inverse U-shaped dependence on NT, mediated—at least in part—by α2- and β-adrenoceptors. We speculate that low doses of NT improve performance by maximizing the phasic release of NE, while higher doses of NT would elevate tonic levels of NE, thus producing suboptimal levels of phasically released NE. Content Type Journal ArticleCategory Original InvestigationPages 1-9DOI 10.1007/s00213-012-2635-yAuthors Swagata Roychowdhury, Laboratory of Synaptic and Cellular Physiology, School of Behavioral and Brain Sciences, University of Texas at Dallas/GR41, 800 West Campbell Road, Richardson, TX 75080, USAZulma Peña-Contreras, Laboratory of Synaptic and Cellular Physiology, School of Behavioral and Brain Scien...

More Aggressive Papillary Thyroid Cancer Found In Obese Patients
A review published Online First in the Archives of Surgery reveals that physicians see a greater number of obese patients with advanced stage and more aggressive forms of papillary thyroid cancer (PTC). Thyroid cancer cases in the U.S. are on the increase, with the higher incident rates due to PTC. However, the researchers state that although obesity is a recognized risk factor for various cancers, it remains unclear whether the higher risk of cancer is responsible for the increase or improved detection rates... (Source: Health News from Medical News Today)