AUDIO: What happens in an abortion clinic
BBC Radio 5 live's Victoria Derbyshire went to an abortion clinic to hear what women who want abortions go through. (Source: BBC News | Health | UK Edition)

Vimentin-mediated signaling is required for IbeA{+} E. coli K1 invasion of human brain microvascular endothelial cells
In this report, we demonstrated that vimentin is a primary receptor required for IbeA#x002B; E. coli K1-induced signaling and invasion of HBMEC, based on the following observations. First, E44 (IbeA#x002B; E. coli K1 strain) invasion was blocked by vimentin inhibitors (Withfferin A and Acrylamide), a recombinant protein containing vimentin head domain and an antibody against the head domain, respectively. Secondly, overexpression of GFP-vimentin and GFP-vimentin head domain deletion mutant (VDM) significantly increased and decreased bacterial invasion, respectively. Thirdly, bacterial invasion was positively correlated with phosphorylation of vimentin at serine 82 by calcium calmodulin-dependent kinase II (CaM kinase II) and IbeA#x002B; E. coli-induced phosphorylation of extracellular r...