A Combined Study Using Ligand‐Based Design, Synthesis, and Pharmacological Evaluation of Analogues of the Acetaminophen Ortho‐Regioisomer with Potent Analgesic Activity
A ligand‐based drug design study was performed to acetaminophen regioisomers as analgesic candidates employing quantum chemical calculations at the DFT/B3LYP level of theory and the 6‐31G* basis set. To do so, many molecular descriptors were used such as highest occupied molecular orbital, ionization potential, H–O bond dissociation energies, and spin densities, which might be related to quench reactivity of the tyrosyl radical to give N‐acetyl‐p‐benzosemiquinone‐imine through an initial electron withdrawing or hydrogen atom abstraction. Based on this in silico work, the most promising molecule, orthobenzamol, was synthesized and tested. The results expected from the theoretical prediction were confirmed in vivo using mouse models of nociception such as writhing, paw licking,...div id=medwormpbiMedWorm Message:/i/b Please have a look at this new site driven by MedWorm: a href=http://www.thebreastcancerdaily.com/ target=_blankThe Breast Cancer Daily/a/p/div

Short 'Tarantula' Therapy Helps People With Spider Phobia
A single brief therapy session for adults with a lifelong debilitating spider phobia resulted in lasting changes to the brain's response to fear. The therapy was so successful, the adults were able to touch or hold a tarantula in their bare hands six months after the treatment, reports a new Northwestern Medicine study. This is the first study to document the immediate and long-term brain changes after treatment and to illustrate how the brain reorganizes long-term to reduce fear as a result of the therapy... (Source: Health News from Medical News Today)