Severe Eye Hemorrhages Uncommon in Critically Ill ChildrenSevere Eye Hemorrhages Uncommon in Critically Ill Children
Severe, multilayered retinal hemorrhages, which are often found in cases of abusive head trauma, are rare in a population of critically ill children without a history of abuse, according to a new study. Medscape Medical News (Source: Medscape Today Headlines)div id=medwormpbiMedWorm Sponsor Message:/i/b Have a look at a href=http://www.thepsychologydaily.comThe Psychology Daily/a, the new psychology portal powered by MedWorm, with all the latest psychology news and research updated daily./p/div

Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells
Highlights: ► Glybenclamide is an orally active K-channel blocker widely used for type II diabetes. ► It was found to inhibit PDGF-mediated cellular invasion in ovarian carcinoma cells. ► Thus, K-channel activity is likely to be a new target of anti-metastasis agent.Abstract: It has been demonstrated that potassium channels (K+ channels) play significant roles in some malignant phenotypes. Here, we provide the first evidence that treatment with glybenclamide, an ATP-sensitive K+ channel blocker, inhibited cell migration in an ovarian clear cell carcinoma cell line, ES-2. Treatment with glybenclamide or knockdown by siRNA targeted against K+ channel subunits demonstrated the suppression of ovarian cancer cell invasion, which occurred via inhibition of PDGF-AA secretion. Therefore, our...