Proton Pump Inhibitors to Treat GERD Cause Heartburn Problems
This study indicates unrecognized aspects of PPI withdrawal and is a very strong indication of a clinically significant acid rebound phenomenon that needs to be investigated in proper patient populations.In the randomized double-blind placebo-controlled trial, the scientists investigated whether long-term treatment with a PPI could cause a dependency state. Specifically, they wanted to see if patients would need non-stop, continuous treatment with the drugs due to rebound acid hypersecretion when the medications were stopped. In all, 120 healthy participants were randomized to about three months of taking inactive placebo pills or 40 mg. of the PPI drug esomeprazole (brand names: Nexium, Esotrex) daily. This was followed by having all the research subjects take a placebo for another four ...

HIV Risk and Substance Use in Men Who Have Sex with MenHIV Risk and Substance Use in Men Who Have Sex with Men
Should HIV prevention measures differ by venue of recruitment? AIDS and Behavior (Source: Medscape Today Headlines)