Appropriateness and complications of the use of spironolactone in patients treated in a heart failure clinic.
Authors: Goland S, Naugolny V, Korbut Z, Rozen I, Caspi A, Malnick S The widespread use of spironolactone in patients with congestive heart failure (CHF) has resulted in side effects and complications. We analyzed a cohort of patients treated by a dedicated CHF team, in order to examine the tolerability and safety of spironolactone in clinical practice. PMID: 21767763 [PubMed - in process] (Source: European Journal of Internal Medicine)

Recent Advancements in the Treatment of Resistant Hypertension
Donald Clark III, MD; Jason L. Guichard, MD, PhD; David A. Calhoun, MD; and Mustafa I. Ahmed, MD DOI: 10.3810/pgm.2012.01.2519 Abstract: The 2008 scientific statement from the American Heart Association defined resistant hypertension as blood pressure remaining above goal (lt; 140/90 mm Hg for the general population and lt; 130/80 mm Hg for patients with diabetes or renal disease) despite the concurrent use of optimal doses of 3 antihypertensive agents of different classes, ideally including a diuretic. Since then, there has been increasing recognition and characterization of patients with resistant hypertension and development of treatment strategies to treat this high-risk population. The role of aldosterone in resistant hypertension has gained increasing recognition. In particul...