Identification of Cytokines and Signaling Proteins Differentially Regulated by Sumatriptan/Naproxen.
Conclusion.- We found that the combination of sumatriptan/naproxen was effective in blocking capsaicin stimulation of pro-inflammatory proteins implicated in the development of peripheral and central sensitization in response to capsaicin activation of trigeminal neurons. Based on our findings that sumatriptan and naproxen regulate expression of different proteins in trigeminal ganglia and the spinal trigeminal nucleus, we propose that these drugs function on therapeutically distinct cellular targets to suppress inflammation and pain associated with migraine. PMID: 22150557 [PubMed - as supplied by publisher] (Source: Headache)

SUMATRIPTAN SUCCINATEinjection, Solution [Sandoz Inc]
Updated Date: Jan 18, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))