Involvement of an ATP-dependent protease (PA0779/AsrA) in inducing heat shock in response to tobramycin in Pseudomonas aeruginosa.
In this study, microarray analysis was utilized to examine the gene responses of P. aeruginosa to lethal, inhibitory, and subinhibitory concentrations of tobramycin under aerobic and anaerobic conditions. While prolonged exposure to subinhibitory concentrations of tobramycin predominantly caused increased expression of the efflux pump genes mexXY, the greatest increases in gene expression in response to lethal concentrations of tobramycin involved a number of heat shock genes and the gene PA0779 (renamed here asrA), encoding an alternate Lon protease. Microarray analysis of an asrA::luxCDABE transposon mutant revealed that the induction of heat shock genes in response to tobramycin in this mutant was significantly decreased compared to the parent strain. Expression of asrA was induced from...

Ectopic Pregnancy: An OverviewEctopic Pregnancy: An Overview
The most common locations for extrauterine pregnancies and the recommended management approaches are summarized in this timely overview. Medscape Ob/Gyn (Source: Medscape ObGyn and Womens Health Headlines)