Spironolactone and hydrochlorothiazide exert antioxidant effects and reduce vascular matrix metalloproteinase-2 activity and expression in a model of renovascular hypertension
Conclusions and implications: SPRL or HCTZ, alone or combined, exerted antioxidant effects, and decreased renovascular hypertension-induced MMP-2 up-regulation, thus improving the vascular dysfunction and remodelling found in this model of hypertension. (Source: British Journal of Pharmacology)

South Sudan: End of the Road for Leper Colony
[IRIN] Juba - A once bustling community of several thousand people on the outskirts of South Sudan's capital, Juba, has been replaced by groups of people huddled under trees, surrounded by bundles piled high and the rubble that was their homes. (Source: AllAfrica News: Health and Medicine)