The Role of Blood Pressure and the Renin-Angiotensin System in Development of Diabetic Nephropathy (DN) in eNOS-/- db/db Mice.
Authors: Zhang MZ, Wang S, Yang S, Yang H, Fan X, Takahashi T, Harris RC Abstract Randomized clinical trials have clearly shown that inhibition of the renin-angiotensin system (RAS) will slow the rate of progression of diabetic nephropathy, but controversy remains about whether the observed beneficial effects result from more than control of blood pressure. Deletion of eNOS in a model of type II diabetes, db/db mice (eNOS(-/-) db/db), induces an accelerated nephropathy and provides an excellent model of human diabetic nephropathy. As is frequently seen in type II diabetes, blood pressure is moderately elevated in eNOS(-/-) db/db mice. In order to determine the role of elevated blood pressure per se versus additional deleterious effects of the renin-angiotensin system in mediation o...

Vigorous Physical Activity Reduces Risk Of Psoriasis
Psoriasis is one of those poorly understood, autoimmune diseases that can cause a person misery. Red and white hues of scaly, patchy skin appear on the top layer of the skin, known as the epidermis. Research published Monday in Archives of Dermatology, a JAMA Network publication, shows how to reduce the risk of Psoriasis. It appears that vigorous activity can reduce the risk of the disease, which has been associated with type 2 diabetes, colon cancer, coronary artery disease and breast cancer. Researchers go on to say: Our results suggest that participation in at least 20... (Source: Health News from Medical News Today)