AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDEtablet [Med Health Pharma LLC.]
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Dual separation mode for simultaneous determination of antihypertensive drug combinations by high-performance liquid chromatography.
Authors: Ahmed S, Atia NN, Mohamed NA
A simple, reproducible and efficient dual separation mode high performance liquid chromatographic (HPLC) method was developed for simultaneous determination of antihypertensive drug combinations including; hydrochlorothiazide (HCTZ), valsartan (VAL), amiloride (AML) and captopril (CAP). The newly developed Platinum™ column, which provides a dual-mode separation with its polar and non-polar sites, was used for rapid separation of these co-administered drugs. Good resolution was obtained when Platinum™ column was used compared with C(18) column. Additionally, simple isocratic mode with mobile phase containing methanol and 0.02moleL(-1) phosphate buffer adjusted to pH 3.0 (45:55, v/v) was used for separation. The flow rate was 0.5mLmin(-1) and eff...div id=medwormpbiMedWorm Message:/i/b Please support the a href=http://www.doctorsinchains.org/ target=_blankDoctors In Chains/a campaign for the a href=http://www.doctorsinchains.org/medics/a tortured and sentenced for up to 15 years in a href=http://www.doctorsinchains.org/Bahrain/a. a href=https://twitter.com/#!/search/%23FreeDoctors#FreeDoctors/a/p/div
