Adverse Drug Reactions and Drug Interactions as Causes of Hospital Admission in Oncology
Conclusion: Approximately one in 10 unplanned hospitalizations of cancer patients is associated with an ADE. Prospective and population-based studies are warranted to evaluate their magnitude in oncology. (Source: Journal of Pain and Symptom Management)
Streptozotocin-induced experimental diabetes causes a time-dependent inhibition of growth and steroidogenic capacity of rat adrenal zona glomerulosa
Summarynbsp;nbsp;The effects of streptozotocin-induced experimental diabetes on the morphology and secretory activity of the zona glomerulosa
were studied in rats whose hypothalamo-hypophyseal-adrenal axes and renin-angiotensin systems had been pharmacologically interrupted
by the simultaneous administration of dexamethasone-captopril and maintenance doses of ACTH-angiotensin II. The animals were
examined 7, 14, 21, and 28 days after diabetes induction, which was evidenced by conspicuous hyperglycemia. Experimental diabetes
caused notable atrophy of the zona glomerulosa and its cells, along with a significant decrease in both basal and angiotensin
II-stimulated plasma aldosterone concentration. There was a positive linear correlation between all these changes and the
number of days...
