Patient Sensitivity To Important Drug Target In Deadly Brain Cancer Predicted
A recent discovery by Van Andel Research Institute (VARI) scientists enables the prediction of patient sensitivity to proposed drug therapies for glioblastoma - the most common and most aggressive malignant brain tumor in humans. The study, published in the Proceedings of the National Academy of Science, investigated glioblastoma models characterized by cell signaling activation and gene amplification for their susceptibility to inhibitors of both the human MET oncogene and the epidermal growth factor receptor (EFGR). An oncogene is a gene with the potential to cause cancer... (Source: Health News from Medical News Today)
Early serous macular detachment after phacoemulsification surgery
We report 2 cases of serous macular detachment with intraretinal fluid accumulation that developed 1 day after uneventful phacoemulsification surgery. Because of a dilution error, both eyes received 2 mg/0.1 mL of intracameral cefuroxime at the end of surgery. On postoperative day 1, the corrected distance visual acuity (CDVA) was 20/400 in both eyes. Optical coherence tomography revealed intraretinal fluid accumulation with serous macular detachment, and central foveal thickness measurements were 909 μm and 559 μm in Case 1 and Case 2, respectively. Case 1 responded to systemic acetazolamide, but the condition recurred after cessation of therapy; it then responded to systemic steroid treatment. Case 2 responded to an intravitreal injection of 4 mg of triamcinolone and remained stable th...
