Severe Hypertension Following Accidental Clonidine Overdose During the Refilling of an Implanted Intrathecal Drug Delivery System
Conclusion: Inadvertent injection into the subcutaneous pocket rather than the reservoir is rare but very dangerous as the drug cannot be retrieved and massive doses are involved. Signs and symptoms of systemic overdose with drugs commonly used in implanted drugs delivery system should be well known to ensure early diagnosis and treatment. (Source: Neuromodulation)
The effect of piribedil on l-DOPA-induced dyskinesias in a rat model of Parkinson’s disease: differential role of α2 adrenergic mechanisms
Abstractnbsp;nbsp;Piribedil is a non-ergoline, dopamine D2/D3 receptor agonist with α2 adrenoceptor antagonist properties that has been used in the treatment of Parkinson’s disease (PD). Noradrenergic neurotransmission
may be involved in the pathogenesis of dyskinesias induced by chronic treatment with l-DOPA (3,4-dihydroxyphenylalanine, levodopa), but its role in the in vivo action of piribedil or on different subclasses of
abnormal involuntary movements (AIMs) remains unclear. The aims of this study were therefore (1) to investigate the anti-dyskinetic
effects of piribedil on l-DOPA-induced contralateral turning behaviour, locomotive dyskinesias (LD), axial dystonia (AD), orolingual dyskinesia (OD)
and forelimb dyskinesia (FD) and (2) to compare these effects to the α2 adrenoce...
