Dinitrophenol poisoning: a role for early dantrolene?
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Fatal 2,4-dinitrophenol poisoning . . . coming to a hospital near you. Siegmueller C, Narasimhaish R. Emerg Med J 2010 May 29 [Epub ahead of print]
Abstract
Dinitrophenol (DNP) is an industrial chemical used in the manufacture of explosives, herbicides, dyes, and wood preservatives. When ingested, DNP uncouples mitochondrial oxidative phosphorylation, interfering with the cells#8217; ability to store energy as ATP. Instead, the energy is dissipated as heat, causing severe hyperthermia that in case reports has proven very difficult if not impossible to control. In addition, the ATP depletion causes release of calcium from the sarcoplasmic reticulum in muscles. The resulting uncontrolled muscular contraction produces even more heat. Patients with DNP toxicity ofte...
Abused Inhalants Enhance GABA-Mediated Synaptic Inhibition
Neuropsychopharmacology advance online publication, June 3, 2009. doi:10.1038/npp.2009.57
Author: M Bruce MacIver
Keywords: hippocampus, synapse, calcium, dantrolene, ryanodine, endoplasmic reticulum (Source: Neuropsychopharmacology)
