Bioactive metabolites from Penicillium sp. P-1, a fungal endophyte in Huperzia serrata
A chemical study of metabolites of the strain Penicillium sp. P-1, an endophyte from the stems of Huperzia serrata, furnished a new chromone derivative, (2S)-2,3-dihydro-7-hydroxy-6,8-dimethyl-2-[(E)-prop-1-enyl]- chroman-4-one (1), an enantiomer of a known compound, and seven known compounds 2–8. The structure and absolute configuration of 1 were established using spectroscopic methods, including extensive 2D NMR and CD analyses. Cytotoxic activity of compounds
1–3 against HeLa and HepG2 cell lines were evaluated, in which compounds 2 and 3 exhibited marked cytotoxic activity against HeLa cells.
Content Type Journal ArticlePages 1-4DOI 10.1007/s10600-011-9991-4Authors
You-Min Ying, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014 P. R. Chi...
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