Development of validated stability-indicating chromatographic method for the determination of fexofenadine hydrochloride and its related impurities in pharmaceutical tablets
A simple reversed phase high performance liquid chromatographic method with diode array detector (HPLC-DAD) has been developed and subsequently validated for the determination of fexofenadine hydrochloride (FEX) and its related compounds; keto fexofenadine (Impurity A), meta isomer of fexofenadine (Impurity B), methyl ester of fexofenadine (Impurity C) in addition to the methyl ester of ketofexofenadine (Impurity D). The separation was based on the use of a Hypersil BDS C-18 analytical column (250 x 4.6 mm, i.d., 5 Micro-m). The mobile phase consisted of a mixture of phosphate buffer containing 0.1 gm% of 1-octane sulphonic acid sodium salt monohydrate and 1% (v/v) of triethylamine, pH 2.7 and methanol (60:40, v/v). The separation was carried out at ambient temperature with a flow rate of ...div id=medwormpbiMedWorm Message:/i/b Find the best a href=http://www.januarysales.org/ target=_blankJanuary Sales/a in the UK./p/div
CVS Earnings Rise 3.7%
CVS Caremark's fourth-quarter profit rose 3.7% as pharmacy-services and retail revenue grew. (Source: WSJ.com: Health)
