Abortion doesn't up risk of mental illness relapse
NEW YORK (Reuters Health) - In women with a history of mental illness such as schizophrenia and bipolar disorder, getting an abortion does not increase their chances of landing in a psychiatric facility again, suggests a new study from Denmark. (Source: Reuters: Health)
Interaction of endothelial progenitor cells expressing cytosine deaminase in tumor tissues and 5‐fluorocytosine administration suppresses growth of 5‐fluorouracil sensitive liver cancer in mice
SummaryThe drug delivery system to tumor is a critical factor in up‐regulating the effect of anti‐cancer drugs and reducing adverse events. Recent studies indicated selective migration of bone marrow‐derived endothelial progenitor cells (EPC) into tumor tissues. Cytosine deaminase (CD) transforms nontoxic 5‐fluorocytosine (5‐FC) into the highly toxic 5‐fluorouracil (5‐FU). We investigated the anti‐tumor effect of a new CD/5‐FC system with CD cDNA transfected EPC for hepatocellular carcinoma (HCC) in mice.We used human hepatoma cell lines (HuH‐7, HLF, HAK1‐B, KYN‐2, KIM‐1) and rat EPC cell line (TR‐BME‐2). E. coli CD cDNA was transfected into TR‐BME‐2 (CD‐TR‐BME). The inhibitory effect of 5‐FU on the proliferation of hepatoma cell lines and the inhibi...
