Is Deep Brain Stimulation Able to Make Antidepressants Effective in Resistant Obsessive-Compulsive Disorder?
Deep brain stimulation (DBS), a nonablative, reversible, and adjustable neurosurgical procedure, has recently been considered as a potential therapeutic alternative for the management of resistant obsessive-compulsive disorder (OCD). The ventral striatum (VS) has been proposed as a subcortical target of special interest for DBS (). It has been extensively demonstrated to play a major role in the pathophysiology of OCD regarding convergent functional neuroimaging data and electrophysiologic recordings (). Here, we report the long-term course of OC symptoms during DBS of the VS and following its discontinuation in two patients suffering from severe, chronic, and incapacitating OCD and showing unsatisfactory responses to 1) the serotonin reuptake inhibitor (SRI) antidepressants fluoxetine, se...
Olanzapine, but Not Fluoxetine, Treatment Increases Survival in Activity-Based Anorexia in Mice
Authors: Stephanie J Klenotich, Mariel P Seiglie, Matthew S McMurray, Jamie D Roitman, Daniel Le Grange, Priya Dugad
Stephanie C Dulawa
Keywords: neuropharmacology; animal models; psychiatry and behavioral sciences; eating#47;metabolic disorders; activity-based anorexia; fluoxetine; anorexia nervosa; olanzapine; balb#47;cJ (Source: Neuropsychopharmacology)
