Microvesicles released from rat adipocytes and harbouring glycosylphosphatidylinositol-anchored proteins transfer RNA stimulating lipid synthesis.
Authors: Müller G, Schneider M, Biemer-Daub G, Wied S
Small microvesicles, such as microparticles and exosomes, have been demonstrated to transfer proteins and nucleic acids from a variety of donor to acceptor cells with corresponding (patho)physiological consequences. Recently the in vitro transfer of glycosylphosphatidylinositol (GPI)-anchored proteins from microvesicles released from large rat adipocytes to intracellular lipid droplets (LD) of small adipocytes has been shown to be upregulated by physiological (palmitate, H(2)O(2)) and pharmacological (anti-diabetic sulfonylurea drug glimepiride) stimuli and to increase the esterification into as well as to reduce the release of fatty acids from triacylglycerol. Here microvesicles derived from (preferentially large) rat adipocytes o...
Mental health at work: Creating safe workplaces
Research shows that one in five Canadians will experience a mental illness in their lifetime but employees are still unsure how to address psychological health in the workplace. (Source: CTV Health)
