Chronic treatment with a glucokinase activator delays the onset of hyperglycaemia and preserves beta cell mass in the Zucker diabetic fatty rat
Conclusions/interpretationnbsp;nbsp;These findings suggest that chronic activation of glucokinase preserves beta cell mass and delays disease in the ZDF rat,
a model of insulin resistance and progressive beta cell failure.
Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2439-3Authors
M. Futamura, Banyu Tsukuba Research Institute, MSD K.K., 3 Okubo, Tsukuba, Ibaraki 300-26, JapanJ. Yao, Departments of Metabolic Disorders and Pharmacology, Merck Sharp Dohme Corp., Whitehouse Station, NJ 0889, USAX. Li, Departments of Metabolic Disorders and Pharmacology, Merck Sharp Dohme Corp., Whitehouse Station, NJ 0889, USAR. Bergeron, Departments of Metabolic Disorders and Pharmacology, Merck Sharp Dohme Corp., Whitehouse Station, NJ 0889, USAJ.-L. Tran, ...
GLUCOTROL (Glipizide) Tablet [Roerig]
Updated Date: Jun 9, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
