Adverse effects and adherence to treatment of rifampicine 4 months vs isoniazid 6 months for latent tuberculosis.
CONCLUSION: A 4-month RIF treatment was associated with significantly less interruption of treatment because of hepatotoxicity and higher completion rates compared to a 6-month INH regimen. These results support the RIF regimen as an alternative to the presently recommended 9 months of INH in clinical practice.
PMID: 21842452 [PubMed - in process] (Source: Swiss Medical Weekly)
New series of isoniazid hydrazones linked with electron-withdrawing substituents.
Authors: Vavříková E, Polanc S, Kočevar M, Košmrlj J, Horváti K, Bősze S, Stolaříková J, Imramovský A, Vinšová J
Abstract
A series of new isoniazid hydrazones was synthesized by two procedures. In the first isoniazid was activated with diethoxymethyl acetate and condensed with the appropriate anilines. Alternatively, substituted anilines were activated by diethoxymethyl acetate and subsequently condensed with isoniazid. NMR study confirmed that both synthetic approaches gave the same tautomer. All compounds were screened for in vitro antimycobacterial activity. Most of them exhibited the same activity against Mycobacterium tuberculosis (MIC 1 μmol L(-1)) as isoniazid (INH), better activity against Mycobacterium kansasii 325/80 (MIC 0.125-0.250 μmol L(-1)), high ...
