Effects of lovastatin on the pharmacokinetics of nicardipine in rats
Abstract (Source: Biopharmaceutics and Drug Disposition)
Immunomodulatory Effects of IFN-β and Lovastatin on Immunophenotype of Monocyte-Derived Dendritic Cells in Multiple Sclerosis
Abstractnbsp;nbsp;Multiple sclerosis (MS) is an autoimmune disease of the central nervous system and current MS treatment is only partially
effective. Recent data suggest that statins may be potent immunomodulatory agents. In order to evaluate their role in MS,
we analyzed the in vitro effects of interferon (IFN)-β and lovastatin on the differentiation and maturation of monocyte-derived
dendritic cells (DCs) of MS patients. Twenty-seven patients with relapsing–remitting MS were recruited for the study. DC differentiation
and maturation were evaluated based on surface phenotypic changes and the expressions of CD14, CD83, CD1a, CD80, CD86, CD206,
and C209 were analyzed by flow cytometry. The results showed that IFN-β and lovastatin affect DC phenotype. Both agents decrease
the ex...
