Clinical relevance of thiopurine S-methyltransferase gene polymorphisms.
Authors: Mladosievicova B, Dzurenkova A, Sufliarska S, Carter A
The therapeutic response to thiopurines may result in either severe toxic or inadequate effect based on the interindividual genetic variability. Same drug doses of various anticancer drugs cause considerable interindividual differences in the therapeutic response. Genetic factors have a major impact on effectiveness of several anticancer drugs such as mercaptopurine, 5-fluorouracil, platinum agents, and cyclophosphamide. Heredity related differences in interindividual response to thiopurine therapy represent perhaps the most compelling evidence of pharmacogenomics' usefulness in identification of patients in risk for adverse drug reactions. A number of variations in the gene for thiopurine methyltransferase (TPMT) have b...
Is your doctor lying to you? New study says it's likely
More than 50 percent of surveyed doctors give patients rosy prognosis, 20 percent don't tell patients they made mistake (Source: Health News: CBSNews.com)
