Sun Pharma gets USFDA nod for nasal spray Astelin
Sun Pharmaceutical Industries has received approval from the US health regulator to sell its generic version of Astelin, used in treating nasal allergies. (Source: The Economic Times Healthcare and Biotech News)
Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures.
Authors: Abraham J, Fox PD, Condello C, Bartolini A, Koh S
Abstract
Innate immunity mediated by microglia appears to play a crucial role in initiating and propagating seizure-induced inflammatory responses. To address the role of activated microglia in the pathogenesis of childhood epilepsy, we first examined the time course of microglia activation following kainic acid-induced status epilepticus (KA-SE) in Cx3cr1(GFP/+) transgenic mice whose microglia are fluorescently labeled. We then determined whether this seizure-induced microglia activation primes the central immune response to overreact and to increase the susceptibility to a second seizure later in life. We used an inhibitor of microglia activation, minocycline, to block the seizure-induced inflammation to determine whether...
