Hemodynamic effects of nisoldipine, a highly specific calcium antagonist, in patients with acute myocardial infarction
Summary??The aim of the study was to investigate the hemodynamic effects of a short-acting, potent, highly specific calcium antagonist, nisoldipine, in patients with acute myocardial infarction. Twenty-four patients were selected on the basis of an elevated wedge pressure and/or elevated blood pressure, less than 12 hours after the onset of symptoms. Patients were randomized to receive either placebo or lowdose nisoldipine (2 ?g/kg) as a single intravenous injection over a 3-minute period. Hemodynamic effects were monitored for 20 minutes, and thereafter patients were crossed over to the other agent after the preserved parameters had returned to baseline. An open-label study using double the dose of nisoldipine in 20 patients who had not reacted adversely to low-dose nisoldipine followed. ...
Premature Death Rates Among Black Women With Sarcoidosis
A new study conducted by researchers from Boston University has found that sarcoidosis accounts for 25 percent of all deaths among women in the Black Women's Health Study who have the disease. The study is the largest epidemiologic study to date to specifically address mortality in black females with sarcoidosis. Results of the study were presented at the ATS 2012 International Conference in San Francisco. The exact cause of sarcoidosis, which causes inflammation in the lungs, lymph nodes, liver, skin and other tissues, are unknown... (Source: Health News from Medical News Today)
