Application of oxybutynin selective sensors for monitoring the dissolution profile and assay of pharmaceutical dosage forms.
Authors: El Hamshary MS, Salem OH, El Nashar RM
Two ion-selective sensors of the plastic membrane type were prepared for the determination of oxybutynin hydrochloride (OxCl). They depend on the incorporation of the ion-associates with phosphotungestic acid or phosphomolybdic acid in a PVC matrix. A comparative study is made between their performance characteristics in batch and FIA conditions. The sensors have nearly the same usable concentration, temperature and pH range. They have a wide range of selectivity and can be applied for the determination of the relevant drug with nearly the same precision and accuracy in vitro. Dissolution testing was applied using the sensors; this offers a simple, rapid, cheap way out of sophisticated and high cost instruments used in the pharmacopeial m...
Risk of Serious Falls Associated With Oxybutynin and Tolterodine: A Population Based Study. - Gomes T, Juurlink DN, Ho JM, Schneeweiss S, Mamdani MM.
PURPOSE: We compared the short-term risk of falls among recipients of oxybutynin or tolterodine to treat urinary incontinence. MATERIALS AND METHODS: We conducted a population based, retrospective cohort study with propensity score matching among patients ... (Source: SafetyLit: All (Unduplicated))div id=medwormpbiMedWorm Message:/i/b Please support the a href=http://www.doctorsinchains.org/ target=_blankDoctors In Chains/a campaign for the a href=http://www.doctorsinchains.org/medics/a tortured and sentenced for up to 15 years in a href=http://www.doctorsinchains.org/Bahrain/a. a href=https://twitter.com/#!/search/%23FreeDoctors#FreeDoctors/a/p/div
