A component of Premarin(®) enhances multiple cognitive functions and influences nicotinic receptor expression.
Authors: Talboom JS, Engler-Chiurazzi EB, Whiteaker P, Simard AR, Lukas R, Acosta JI, Prokai L, Bimonte-Nelson HA
In women, ovarian hormone loss at menopause has been related to cognitive decline, and some studies suggest that estrogen-containing hormone therapy (HT) can mitigate these effects. Recently, the Women's Health Initiative study found that conjugated equine estrogens, the most commonly prescribed HT, do not benefit cognition. Isolated components of conjugated equine estrogens (tradename Premarin(®)) have been evaluated in vitro, with Î(8,9)-dehydroestrone (â(8)E1) and equilin showing the strongest neuroprotective profiles. It has not been evaluated whether â(8)E1 or equilin impact cognition or the cholinergic system, which is affected by other estrogens and k...
Prempro Maker Says Woman Did Not Rely On Advertising
NEW BRUNSWICK, N.J. - A woman's claims based on Wyeth's direct-to-consumer (DTC) advertising should be dismissed with prejudice because she admitted that she did not rely on them when deciding to use Premarin and Prempro and because she has not provided any evidence that the advertisements violated Food and Drug Administration regulations, the maker of the drugs says in a May 5 motion (In re: HRT Litigation, Case No. 266; Loretta Deboard v. Wyeth Inc., et al., No. MID-L-1147-06 MT, N.J. Super., Middlesex Co.; See related stories in this issue).
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