Half Million IV Devices Recalled Due to Possible Safety RisksHalf Million IV Devices Recalled Due to Possible Safety Risks
The maker of an intravenous administration device has issued a voluntary recall for nearly 545,000 of its products. News Alerts (Source: Medscape Today Headlines)
The potassium channel subunit Kv#x03B2;3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials
Pannexin 1 (Panx1), a member of the second gap junction protein family identified in vertebrates, appears to preferentially form non-junctional membrane channels. A candidate regulatory protein of Panx1 is the potassium channel subunit Kv[beta]3, previously identified by bacterial two-hybrid strategies. Here, we report on the physical association of Panx1 with Kv[beta]3 by immunoprecipitation when co-expressed in a neuroblastoma cell line (Neuro2A). Furthermore, in vivo co-expression of Panx1 and Kv[beta]3 was shown to occur in murine hippocampus and cerebellum. Kv[beta]3 is known to accelerate inactivation of otherwise slowly inactivating potassium channels under reducing conditions. We subsequently found that Panx1 channel currents exhibit a significant reduction when exposed to reducing...
