Involuntary Emotional Expression Disorder
, or IEED, is a condition in which a person experiences uncontrollable episodes of emotional expression. That is, they have episodes of crying, laughter, or anger that are not in line with their present mood.
The condition is also known as labile affect, pseudobulbar affect, emotional lability, and pathological laughing and crying. It can have a severe impact on the lives of both patients and caregivers, as symptoms may leave sufferers feeling guilty, awkward, embarrassed and reluctant to take part in social interaction.
IEED is seen most often following brain injury or in people with dementia, motor neuron disease, and multiple sclerosis. It can appear at any stage of the associated diseases.
Its prevalence was estimated in 2007 by Walter Bradley, MD, of Miami University. His team survey...
Strattera hard capsules (Atomoxetine hydrochloride)-Revised SPC
Source: eMC (electronic Medicines Compendium)
Area: Other Library Updates #62; SPC Changes
There have been significant updates to several sections of the SPC, including the following:
#160;
Change to section 4.4 - Special warnings and precautions for Use
#160;
Addition to hepatic effects. Strattera should be discontinued in patients with jaundice or laboratory evidence of liver injury, and should not be restarted.
#160;
Change to section 4.5 - Interaction with other medicinal products and other forms of interaction
#160;
CYP2D6 inhibitors (SSRIs (e.g. fluoxetine, paroxetine), quinidine, terbinafine): In patients receiving these drugs, atomoxetine exposure may be 6-to 8-fold increased and Css max 3 to 4 times higher, because it metabolised by...
