Hyperandrogenism sensitizes mononuclear cells to promote glucose-induced inflammation in lean reproductive-age women
Hyperandrogenism and chronic low-grade inflammation are related in polycystic ovary syndrome (PCOS), but it is unknown whether hyperandrogenemia can activate inflammation. We determined the effect of oral androgen administration on fasting and glucose-stimulated nuclear factor-B (NF-B) activation and expression and related markers of inflammation in mononuclear cells (MNC) of lean reproductive-age women. Sixteen lean, ovulatory reproductive-age women were treated with 130 mg of DHEA or placebo (n = 8 each) for 5 days in a randomized, controlled, double-blind fashion. Nuclear activation of NF-B, p65 and p105 NF-B subunit RNA, TNFalpha; and IL-1beta; mRNA, and NF-B p65 and inhibitory-B (IB) protein were quantified from MNC obtained while fasting and 2 h after glucose ingestion, before and ...div id=medwormpbiMedWorm Message:/i/b Find the best a href=http://www.januarysales.org/ target=_blankJanuary Sales/a in the UK./p/div
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